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Macromolecular Structure and Function

Paul Freemont

Paul Freemont

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Professor Paul Freemont – Chair of Protein Crystallography

Paul Freemont is Chair of Protein Crystallography and currently Head of the Division of Molecular Biosciences at Imperial College London.  He joined Imperial in 2000 as Director of the Centre for Structural Biology leaving the CRUK London Institute where he established experimental Structural Biology research.  His own interdisciplinary research interests have focused on understanding how disease-linked proteins work at the molecular level and he has made several important contributions in this field including the identification and naming of a novel protein domain (RING finger) found in many cancer-linked proteins including BRCA1 and MDM2.

He has also determined a number of important crystal structures including the human DNA repair enzyme Ape-1, XRCC1 BRCT domain, procine spasmolytic polypeptide, and the disease associated ATPase p97.  In addition his laboratory has a strong interest in nuclear cell biology, which was driven by the co-discovery of SUMO-1 as a modifier of the Acute Promyelocytic Leukaemia associated PML protein.  He has recently developed new quantitative approaches to aid the understanding of mammalian interphase nuclear organisation.  In addition to his research interests, he has served on the Molecules, Genes and Cells Wellcome Trust panel, chaired the Imperial Life Science Infrastructure committee, coordinated the development of high-field NMR and Imaging facilities at Imperial and sits on the Scientific Advisory Board of the Chemical Biology Centre.