Paul Freemont's Publications
2012 (5)
147 — original research
Niwa H, Ewens CA, Tsang C, Yeung HO, Zhang X, Freemont PS
"The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP"
J Biol Chem 278:8561-70 (2012) – [Pubmed]
146 — book
Baldwin G, Bayer T, Ellis T, Dickinson R, Bart-Stan G, Polizzi K, Kitney R, Freemont PS
Synthetic biology – a primer
Imperial College Press (2012)
145 — original research
Bebeacua C, Förster A, McKeown C, Meyer HH, Zhang X, Freemont PS
"Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy"
Proc Natl Acad Sci USA 109:1098-103 (2012) – [Pubmed]
144 — original research
Silhan J, Nagorska K, Zhao Q, Jensen K, Freemont PS, Tang CM, Baldwin GS
"Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis"
Nucleic Acids Res 40:2065-75 (2012) – [Pubmed]
143 — review article
Kloppsteck P, Ewens CA, Förster A, Zhang X, Freemont PS
"Regulation of p97 in the Ubiquitin-Proteasome System by the UBX protein-family"
Biochim Biophys Acta 1823:125-9 (2012) – [Pubmed]
2011 (6)
142 — conference proceedings
Chappell J, Freemont PS
"Synthetic biology–A New Generation of Biofilm Biosensors"
in The Science and Applications of Synthetic and Systems Biology, Institute of Medicine of the National Academies USA, Forum on Microbial Threats (2011)
141 — book chapter
Batty E, Jensen K, Freemont PS
"PML bodies and other TRIM-defined subcellular compartments"
in TRIM/RBCC proteins (edited by Meroni G), Landes Biosciences (2011)
140 — original research
Lossi NS, Dajani R, Freemont P, Filloux A
"Structure-function analysis of HsiF, a gp25-like component of the type VI secretion system, in Pseudomonas aeruginosa"
Microbiology 157:3292-305 (2011) – [Pubmed]
139 — original research
Attia M, Förster A, Rachez C, Freemont P, Avner P, Rogner UC
"Interaction between Nucleosome Assembly Protein 1-like family members"
J Mol Biol 407:647-60 (2011) – [Pubmed]
138 — review article
Macdonald JT, Barnes C, Kitney RI, Freemont PS, Stan GB
"Computational design approaches and tools for synthetic biology"
Integr Biol (Camb) 3:97-108 (2011) – [Pubmed]
137 — book chapter
Russell RA, Adams NM, Stephens D, Batty E, Jensen K, Freemont PS
"Methodology for Quantitative Analysis of 3-D Nuclear Architecture"
in Advances in Nuclear Architecture (edited by Adams NM and Freemont PS), Springer (2011) – [DOI]
2010 (2)
136 — original research
Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali S
"A Novel Pyrazolo[1,5-a]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration"
J Med Chem 53:8508:22 (2010) – [Pubmed]
135 — review article
Ewens CA, Kloppsteck P, Förster A, Zhang X, Freemont PS
"Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97"
Biochem Cell Biol 88:41-8 (2010) – [Pubmed]
2009 (6)
134 — book chapter
Jensen K, Sternsdorf T, Freemont PS
"Historical Introduction to SUMO Modification"
in Sumoylation: Molecular Biology and Biochemistry (edited by Wilson VG), Taylor & Francis (2009)
133 — original research
Xu Y, Liu M, Simpson PJ, Isaacson R, Cota E, Marchant J, Yang D, Zhang X, Freemont P, Matthews S
"Automated assignment in selectively methyl-labeled proteins"
J Am Chem Soc 131:9480-1 (2009) – [Pubmed]
132 — review article
Gulati S, Rouilly V, Niu X, Chappell J, Kitney RI, Edel JB, Freemont PS, deMello AJ
"Opportunities for microfluidic technologies in synthetic biology"
J R Soc Interface 6:S493-506 (2009) – [DOI]
131 — original research
Russell RA, Adams NM, Stephens DA, Batty E, Jensen K, Freemont PS
"Segmentation of fluorescence microscopy images for quantitative analysis of cell nuclear architecture"
Biophys J 96:3379-3389 (2009) – [Pubmed]
130 — review article
Batty E, Jensen K, Freemont P
"PML nuclear bodies and their spatial relationships in the mammalian cell nucleus"
Front Biosci 14:1182-96 (2009) – [Pubmed]
129 — original research
Lu D, Wörmann ME, Zhang X, Schneewind O, Gründling A, Freemont PS
"Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS"
Proc Natl Acad Sci USA 106:1584-9 (2009) – [Pubmed]
2008 (4)
128 — review article
Förster A, Freemont PS, Mayer RJ
"AAA proteins and the life process"
Biochem Soc Trans 36:59-61 (2008) – [Pubmed]
127 — original research
Briggs LC, Baldwin GS, Miyata N, Kondo H, Zhang X, Freemont PS
"Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase"
J Biol Chem 283:13745-52 (2008) – [Pubmed]
126 — review article
Yeung HO, Kloppsteck P, Niwa H, Isaacson RL, Matthews S, Zhang X, Freemont PS
"Insights into adaptor binding to the AAA protein p97"
Biochem Soc Trans 36:62-7 (2008) – [Pubmed]
125 — original research
Poh J, Odendall C, Spanos A, Boyle C, Liu M, Freemont P, Holden DW
"SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling"
Cell Microbiol 10:20-30 (2008) – [Pubmed]
2007 (9)
124 — original research
Pye V, Beuron F, Keetch C, McKeown C, Robinson CV, Zhang X, Freemont P
"Structural insights into the p97-Ufd1-Npl4 complex"
Proc Natl Acad Sci USA 104:467-72 (2007) – [Pubmed]
123 — original research
Isaacson R, Simpson P, Liu M, Cota E, Zhang X, Freemont P, Matthews S
"A new labeling method for methyl transverse relaxation-optimized spectroscopy NMR spectra of alanine residues"
J Am Chem Soc 129:15428-9 (2007) – [Pubmed]
122 — original research
Isaacson RL, Pye VE, Simpson P, Meyer HH, Zhang X, Freemont PS, Matthews S
"Detailed structural insights into the p97-Npl4-Ufd1 interface"
J Biol Chem 282:21361-9 (2007) – [Pubmed]
121 — original research
Martin CA, Longman E, Wooding C, Hoosdally SJ, Ali S, Aitman TJ, Gutmann DA, Freemont PS, Byrne B, Linton KJ
"Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins"
Protein Sci 16:2531-41 (2007) – [Pubmed]
120 — original research
Shiels C, Adams NM, Islam SA, Stephens DA, Freemont PS
"Quantitative analysis of cell nucleus organisation"
PLoS Comput Biol 3:e138 (2007) – [Pubmed]
119 — original research
Muzzolini L, Beuron F, Patwardhan A, Popuri V, Cui S, Niccolini B, Rappas M, Freemont PS, Vindigni A
"Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity"
PLoS Biol 5:e20 (2007) – [Pubmed]
118 — original research
Barrett A, Santangelo S, Tan K, Catchpole S, Roberts K, Spencer-Dene B, Hall D, Scibetta A, Burchell J, Verdin E, Freemont P, Taylor-Papadimitriou J
"Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases"
Int J Cancer 121:265-75 (2007) – [Pubmed]
117 — original research
Rytkönen A, Poh J, Garmendia J, Boyle C, Thompson A, Liu M, Freemont P, Hinton JC, Holden DW
"SseL, a Salmonella deubiquitinase required for macrophage killing and virulence"
Proc Natl Acad Sci USA 104:3502-7 (2007) – [Pubmed]
116 — original research
Carpenter EP, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, Kasampalidis I, Exley R, Winterbotham M, Tang C, Baldwin GS, Freemont P
"AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis"
EMBO J 26:1363-72 (2007) – [Pubmed]
2006 (6)
115 — book chapter
Briggs LC, Dreveny I, Pye VE, Beuron F, Mckeown C, Zhang X, Freemont PS
"p97 and Ubiquitin : A complex story"
in Protein Degradation, Vol. 3: Cell Biology of the Ubiquitin-Proteasome System (edited by Ciechanover A, Rechsteiner M, Mayer RJ), Verlag Chemie (2006)
114 — original research
Beuron F, Dreveny I, Yuan X, Pye VE, Mckeown C, Briggs LC, Cliff MJ, Kaneko Y, Wallis R, Isaacson EL, Ladbury JE, Matthews SJ, Kondo H, Zhang X, Freemont PS
"Conformational changes in the AAA ATPase p97-p47 adaptor complex"
EMBO J 25:1967-76 (2006) – [Pubmed]
113 — original research
Uchiyama K, Totsukawa G, Puhka M, Kaneko Y, Jokitalo E, Dreveny I, Beuron F, Zhang X, Freemont P, Kondo H
"p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis"
Dev Cell 11:755-7 (2006) – [Pubmed]
112 — review article
Pye VE, Dreveny I, Briggs LC, Sands C, Beuron F, Zhang X, Freemont PS
"Going through the motions: The ATPase cycle of p97"
J Struct Biol 156:12-28 (2006) – [Pubmed]
111 — original research
McManus KJ, Stephens DA, Adams NM, Islam SA, Freemont PS, Hendzel MJ
"The transcriptional regulator CBP has defined spatial associations within interphase nuclei"
PLoS Comput Biol 2:e139 (2006) – [Pubmed]
110 — original research
Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D
"Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions"
J Cell Biol 164:515-26 (2006) – [Pubmed]
2005 (1)
109 — original research
Madhusudan S, Smart F, Shrimpton P, Parsons JL, Gardiner L, Houlbrook S, Talbot DC, Hammonds T, Freemont PS, Sternberg MJ, Dianov GL, Hickson ID
"Isolation of a small molecule inhibitor of DNA base excision repair"
Nucleic Acids Res 33:4711-24 (2005) – [Pubmed]
2004 (4)
108 — original research
Dreveny I, Kondo H, Uchiyama K, Shaw A, Zhang X, Freemont PS
"Structural Basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47"
EMBO J 23:1030-9 (2004) – [Pubmed]
107 — original research
Yuan X, Simpson P, McKeown C, Kondo H, Uchiyama K, Wallis R, Dreveny I, Keetch C, Zhang X, Robinson C, Freemont P, Matthews S
"Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97"
EMBO J 23:1463-73 (2004) – [Pubmed]
106 — review article
Dreveny I, Pye VE, Beuron F, Briggs LC, Isaacson RL, Matthews SJ, McKeown C, Yuan X, Zhang X, Freemont PS
"p97 and close encounters of every kind: A brief review"
Biochem Soc Trans 32:715-20 (2004) – [Pubmed]
105 — original research
Yuan X, Simpson P, Kondo H, McKeown C, Dreveny I, Zhang X, Freemont PS, Matthews S
"Complete backbone resonance assignments of p47: The 41kDa adaptor protein of the AAA ATPase p97"
J Biomol NMR 28:309-10 (2004) – [Pubmed]
2003 (5)
104 — original research
Beuron F, Flynn TC, Ma J, Kondo H, Zhang X, Freemont PS
"Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model"
J Mol Biol 327:619-29 (2003) – [Pubmed]
103 — original research
Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS
"The crystal structure of murine p97/VCP at 3.6Å"
J Struct Biol 144:337-48 (2003) – [Pubmed]
102 — original research
Jones B, Jones EL, Bonney SA, Patel HN, Mensenkamp AR, Eichenbaum-Voline S, Rudling M, Myrdal U, Annesi G, Naik S, Meadows N, Quattrone A, Islam SA, Naoumova RP, Angelin B, Infante R, Levy E, Roy CC, Freemont PS, Scott J, Shoulders CC
"Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders"
Nat Genet 34:29-31 (2003) – [Pubmed]
101 — review article
Sternsdorf T, Jensen K, Freemont PS
"SUMO"
Curr Biol 13:R258-9 (2003) – [Pubmed]
100 — original research
Tan K, Shaw AL, Madsen B, Jensen K, Taylor-Papadimitriou J, Freemont PS
"Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9"
J Biol Chem 278:20507-13 (2003) – [Pubmed]
2002 (4)
99 — original research
Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H
"VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo"
J Cell Biol 159:855-66 (2002) – [Pubmed]
98 — review article
Zhang X, Beuron F, Freemont PS
"Machinery of protein folding and unfolding"
Curr Opin Struct Biol 12:231-8 (2002) – [Pubmed]
97 — original research
Madsen B, Spencer-Dene B, Poulsom R, Hall D, Lu PJ, Scott K, Shaw AT, Burchell JM, Freemont P, Taylor-Papadimitriou J
"Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer"
Mech Dev 119:S239-46 (2002) – [Pubmed]
96 — original research
Hickabottom M, Parker GA, Freemont P, Crook T, Allday MJ
"Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP)"
J Biol Chem 277:47197-204 (2002) – [Pubmed]
2001 (7)
95 — book chapter
Borden KLB, Freemont PS
"RING domains"
in Encyclopedia of Molecular Medicine, Wiley Interscience (2001)
94 — original research
Yuan X, Shaw A, Zhang X, Kondo H, Lally J, Freemont PS, Matthews S
"Solution structure and interaction surface of the C-terminal domain from p47: A major p97-cofactor involved in SNARE disassembly"
J Mol Biol 311:255-63 (2001) – [Pubmed]
93 — original research
Dulic A, Bates P, Zhang X, Freemont PS, Lindahl T, Barnes D
"BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III"
Biochemistry 40:5906-13 (2001) – [Pubmed]
92 — original research
Shiels C, Islam SA, Vatcheva R, Sasieni P, Sternberg MJ, Freemont PS, Sheer D
"PML bodies associate specifically with the MHC gene cluster in interphase nuclei"
J Cell Sci 114:3705-16 (2001) – [Pubmed]
91 — review article
Jensen K, Shiels C, Freemont PS
"PML protein isoforms and the RBCC/TRIM motif"
Oncogene 20:7223-33 (2001) – [Pubmed]
90 — original research
Moréra S, Larivière L, Kurzeck J, Aschke-Sonnenborn U, Freemont PS, Janin J, Rüger W
"High resolution crystal structures of T4 phage β-glucosyltransferase: induced fit and effect of substrate and metal binding"
J Mol Biol 311:569-77 (2001) – [Pubmed]
89 — original research
Lallemand-Breitenbach V, Zhu J, Puvion F, Koken M, Honoré N, Doubeikovsky A, Duprez E, Pandolfi PP, Puvion E, Freemont P, de Thé H
"Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation"
J Exp Med 193:1361-71 (2001) – [Pubmed]
2000 (7)
88 — original research
Zhang X, Shaw A, Bates P, Newman R, Gowen B, Orlova E, Gorman M, Kondo H, Dokurno P, Lally J, Leonard G, Meyer H, van Heel M, Freemont PS
"Structure of the AAA ATPase p97"
Molecular Cell 6:1473-84 (2000) – [Pubmed]
87 — review article
Huyton T, Bates PA, Zhang X, Sternberg MJ, Freemont PS
"The BRCA1 C-terminal domain: Structure and function"
Mutat Res 460:319-32 (2000) – [Pubmed]
86 — original research
Rothwell DG, Hang B, Gorman MA, Freemont PS, Singer B, Hickson ID
"Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding"
Nucleic Acids Res 28:2207-13 (2000) – [Pubmed]
85 — original research
Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS
"HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties"
J Biol Chem 275:28785-92 (2000) – [Pubmed]
84 — original research
Zhong S, Müller S, Ronchetti S, Freemont PS, Dejean A, Pandolfi PP
"Role of SUMO-1-modified PML in nuclear body formation"
Blood 95:2748-52 (2000) – [Pubmed]
83 — review article
Freemont PS
"RING for destruction?"
Curr Biol 10:R84-7 (2000) – [Pubmed]
82 — original research
Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V
"Biochemical analyses of the AF10 protein: The extended LAP/PHD-finger mediates oligomerisation"
J Mol Biol 299:369-78 (2000) – [Pubmed]
1999 (10)
81 — original research
Moréra S, Imberty A, Aschke-Sonnenborn U, Rüger W, Freemont PS
"T4 phage β-glucosyltransferase: substrate binding and proposed catalytic mechanism"
J Mol Biol 292:717-30 (1999) – [Pubmed]
80 — original research
Karow JK, Newman RH, Freemont PS, Hickson ID
"Oligomeric ring structure of the Bloom's syndrome helicase"
Curr Biol 9:597-600 (1999) – [Pubmed]
79 — original research
Soulez M, Saurin AJ, Freemont PS, Knight JC
"SSX and the synovial-sarcoma-specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex"
Oncogene 18:2739-46 (1999) – [Pubmed]
78 — original research
Duprez E, Saurin AJ, Desterro JM, Lallemand-Breitenbach V, Howe K, Boddy MN, Solomon E, de Thé H, Hay RT, Freemont PS
"SUMO-1 modification of the acute promyelocytic leukaemia protein PML: Implications for nuclear localisation"
J Cell Sci 112:381-93 (1999) – [Pubmed]
77 — review article
Vrielink A, Freemont PS
"Protein-nucleic acid recognition and interactions"
Principles in Medical Biology 5:85-115 (1999)
76 — original research
Müller JM, Rabouille C, Newman R, Shorter J, Freemont P, Schiavo G, Warren G, Shima DT
"An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion"
Nat Cell Biol 1:335-40 (1999) – [Pubmed]
75 — original research
Imberty A, Monier C, Bettler E, Moréra S, Freemont P, Sippl M, Flöckner H, Rüger W, Breton C
"Fold recognition study of α3-galactosyltransferase and molecular modeling of the nucleotide sugar-binding domain"
Glycobiology 9:713-22 (1999) – [Pubmed]
74 — original research
Lu PJ, Sundquist K, Baeckstrom D, Poulsom R, Hanby A, Meier-Ewert S, Jones T, Mitchell M, Pitha-Rowe P, Freemont P, Taylor-Papadimitriou J
"A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer"
J Biol Chem 274:15633-45 (1999) – [Pubmed]
73 — original research
Allford S, Grimwade D, Langabeer S, Duprez E, Saurin A, Chatters S, Walker H, Roberts P, Rogers J, Bain B, Patterson K, McKernan A, Freemont P, Solomon E, Burnett A, Goldstone A, Linch D
"Identification of the t(15;17) in AML FAB types other than M3: Evaluation of the role of molecular screening for the PML/RARalpha rearrangement in newly diagnosed AML. The Medical Research Council (MRC) Adult Leukaemia Working Party"
Br J Haematol 105:198-207 (1999) – [Pubmed]
72 — original research
Assier E, Bouzinba-Segard H, Stolzenberg MC, Stephens R, Bardos J, Freemont P, Charron D, Trowsdale J, Rich T
"Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat"
Gene 230:145-54 (1999) – [Pubmed]
1998 (12)
71 — original research
Zhang X, Moréra S, Bates PA, Whitehead PC, Coffer AI, Hainbucher K, Nash RA, Sternberg MJ, Lindahl T, Freemont PS
"Structure of an XRCC1 BRCT domain: A new protein-protein interaction module"
EMBO J 17:6404-11 (1998) – [Pubmed]
70 — review article
Saha V, Young BD, Freemont PS
"Translocations, fusion genes, and acute leukemia"
J Cell Biochem Suppl 30-31:264-76 (1998) – [Pubmed]
69 — original research
Dokurno P, Bates PA, Band HA, Stewart LM, Lally JM, Burchell JM, Taylor-Papadimitriou J, Snary D, Sternberg MJ, Freemont PS
"Crystal structure at 1.95 Å resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition"
J Mol Biol 284:713-28 (1998) – [Pubmed]
68 — original research
Bates PA, Dokurno P, Freemont PS, Sternberg MJ
"Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody"
J Mol Biol 284:549-55 (1998) – [Pubmed]
67 — review article
Hodges M, Tissot C, Freemont PS
"Protein regulation: Tag wrestling with relatives of ubiquitin"
Curr Biol 8:R749-52 (1998) – [Pubmed]
66 — original research
Lally JM, Newman RH, Knowles PP, Islam S, Coffer AI, Parker M, Freemont PS
"Crystallization of an intact GST-estrogen receptor hormone binding domain fusion protein"
Acta Crystallogr D Biol Crystallogr 54:423-6 (1998) – [Pubmed]
65 — original research
Saurin AJ, Shiels C, Williamson J, Satijn DP, Otte AP, Sheer D, Freemont PS
"The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain"
J Cell Biol 142:887-98 (1998) – [Pubmed]
64 — original research
Hodges M, Tissot C, Howe K, Grimwade D, Freemont PS
"Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies"
Am J Hum Genet 63:297-304 (1998) – [Pubmed]
63 — original research
Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD
"Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML"
J Cell Sci 111:1319-29 (1998) – [Pubmed]
62 — original research
Everett RD, Freemont P, Saitoh H, Dasso M, Orr A, Kathoria M, Parkinson J
"The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms"
J Virol 72:6581-91 (1998) – [Pubmed]
61 — original research
Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G
"Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro"
Cell 92:603-10 (1998) – [Pubmed]
60 — original research
Howe K, Williamson J, Boddy N, Sheer D, Freemont P, Solomon E
"The ubiquitin-homology gene PIC1: Characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes"
Genomics 47:92-100 (1998) – [Pubmed]
1997 (10)
59 — original research
Kondo H, Rabouille C, Newman R, Levine TP, Pappin D, Freemont P, Warren G
"p47 is a cofactor for p97-mediated membrane fusion"
Nature 388:20-1 (1997) – [Pubmed]
58 — original research
Dokurno P, Lally JM, Bates PA, Taylor-Papadimitriou J, Band HA, Snary D, Freemont PS
"Crystallization of an antitumour antibody SM3 complexed with a peptide epitope"
Acta Crystallogr D Biol Crystallogr 53:780-1 (1997) – [Pubmed]
57 — original research
Gorman MA, Moréra S, Rothwell DG, de La Fortelle E, Mol CD, Tainer JA, Hickson ID, Freemont PS
"The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites"
EMBO J 16:6548-58 (1997) – [Pubmed]
56 — original research
Boddy MN, Duprez E, Borden KL, Freemont PS
"Surface residue mutations of the PML RING finger domain alter the formation of nuclear matrix-associated PML bodies"
J Cell Sci 110:2197-205 (1997) – [Pubmed]
55 — original research
Dokurno P, Lally JM, Bates PA, Band HA, Snary D, Freemont PS
"Crystallization of the Fab fragment of the tumour-specific antibody PR1A3"
Acta Crystallogr D Biol Crystallogr 53:472-3 (1997) – [Pubmed]
54 — original research
Cao T, Borden KL, Freemont PS, Etkin LD
"Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution"
J Cell Sci 110:1563-71 (1997) – [Pubmed]
53 — original research
Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP
"RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor"
Mol Cell Biol 17:4105-13 (1997) – [Pubmed]
52 — original research
Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F, Walker H, Culligan D, Waters J, Pomfret M, Goldstone A, Burnett A, Freemont P, Sheer D, Solomon E
"Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia"
Blood 90:4876-85 (1997) – [Pubmed]
51 — original research
Kondo H, Rabouille C, Newman R, Levine TP, Pappin D, Freemont P, Warren G
"p47 is a cofactor for p97-mediated membrane fusion"
Nature 388:75-8 (1997) – [Pubmed]
50 — original research
Rothwell DG, Barzilay G, Gorman M, Moréra S, Freemont P, Hickson ID
"The structure and functions of the HAP1/Ref-1 protein"
Oncol Res 9:275-80 (1997) – [Pubmed]
1996 (8)
49 — original research
Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS
"PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia"
Oncogene 13:971-82 (1996) – [Pubmed]
48 — review article
Borden KL, Freemont PS
"The RING finger domain: A recent example of a sequence-structure family"
Curr Opin Struct Biol 6:395-401 (1996) – [Pubmed]
47 — review article
Saurin AJ, Borden KL, Boddy MN, Freemont PS
"Does this have a familiar RING?"
Trends Biochem Sci 21:208-14 (1996) – [Pubmed]
46 — original research
Borden KL, Lally JM, Martin SR, O'Reilly NJ, Solomon E, Freemont PS
"In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML"
Proc Natl Acad Sci USA 93:1601-6 (1996) – [Pubmed]
45 — review article
Brown DG, Freemont PS
"Crystallography in the study of protein-DNA interactions"
Methods Mol Biol 56:293-318 (1996) – [Pubmed]
44 — original research
Newman RH, Freemont P
"Use of planar lipid monolayers for 2D crystallisation of proteins and simple analysis of specific lipid-peptide interactions"
Thin Solid Films 284-285:18-23 (1996)
43 — original research
Newman RH, Whitehead P, Lally J, Coffer A, Freemont P
"20S human proteasomes bind with a specific orientation to lipid monolayers in vitro"
Biochim Biophys Acta 1281:111-6 (1996) – [Pubmed]
42 — original research
Otto WR, Rao J, Cox HM, Kotzian E, Lee CY, Goodlad RA, Lane A, Gorman M, Freemont PS, Hansen HF, Pappin D, Wright NA
"Effects of pancreatic spasmolytic Polypeptide (PSP) on epithelial cell function"
Eur J Biochem 235:64-72 (1996) – [Pubmed]
1995 (4)
41 — original research
Borden KL, Lally JM, Martin SR, O'Reilly NJ, Etkin LD, Freemont PS
"Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development"
EMBO J 14:5947-56 (1995) – [Pubmed]
40 — original research
Borden KL, Boddy MN, Lally J, O'Reilly NJ, Martin S, Howe K, Solomon E, Freemont PS
"The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML"
EMBO J 14:1532-41 (1995) – [Pubmed]
39 — original research
Seckl MJ, Newman RH, Freemont PS, Rozengurt E
"Substance P-related antagonists inhibit vasopressin and bombesin but not 5'-3-O-(thio)triphosphate-stimulated inositol phosphate production in Swiss 3T3 cells"
J Cell Physiol 163:87-95 (1995) – [Pubmed]
38 — original research
Chinery R, Bates PA, De A, Freemont PS
"Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers"
FEBS Lett 357:50-4 (1995) – [Pubmed]
1994 (4)
37
Vrielink A, Rüger W, Driessen HP, Freemont PS
"Crystal structure of the DNA modifying enzyme β-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose"
EMBO J 13:3413-22 (1994) – [Pubmed]
36
Boddy MN, Freemont PS, Borden KL
"The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger"
Trends Biochem Sci 19:198-9 (1994) – [Pubmed]
35
Newman RH, Carpenter E, Freemont PS, Blundell TL, Parker PJ
"Microcrystals of the β1 isoenzyme of protein kinase C: An electron microscopic study"
Biochem J 298:391-3 (1994) – [Pubmed]
34
De A, Brown DG, Gorman MA, Carr M, Sanderson MR, Freemont PS
"Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors"
Proc Natl Acad Sci USA 91:1084-8 (1994) – [Pubmed]
1993 (4)
33
Borden KL, Martin SR, O'Reilly NJ, Lally JM, Reddy BA, Etkin LD, Freemont PS
"Characterisation of a novel cysteine/histidine-rich metal binding domain from Xenopus nuclear factor XNF7"
FEBS Lett 335:255-60 (1993) – [Pubmed]
32
Freemont PS
"The RING finger. A novel protein sequence motif related to the zinc finger"
Ann N Y Acad Sci 684:174-92 (1993) – [Pubmed]
31
Lovering R, Hanson IM, Borden KL, Martin S, O'Reilly NJ, Evan GI, Rahman D, Pappin DJ, Trowsdale J, Freemont PS
"Identification and preliminary characterization of a protein motif related to the zinc finger"
Proc Natl Acad Sci USA 90:2112-6 (1993) – [Pubmed]
30 — review article
Freemont P
"Structural biology. Max in a complex affair"
Nature 363:20-1 (1993) – [Pubmed]
1992 (5)
29
Gorman MA, De A, Freemont PS
"Crystallization and preliminary X-ray diffraction studies of pancreatic spasmolytic polypeptide"
J Mol Biol 228:991-4 (1992) – [Pubmed]
28
Campbell IG, Freemont PS, Foulkes W, Trowsdale J
"An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains"
Cancer Res 52:5416-20 (1992) – [Pubmed]
27
Reddy BA, Etkin LD, Freemont PS
"A novel zinc finger coiled-coil domain in a family of nuclear proteins"
Trends Biochem Sci 17:344-5 (1992) – [Pubmed]
26
Driessen HP, Newman RH, Freemont PS, Crumpton MJ
"A model of the structure of human annexin VI bound to lipid monolayers"
FEBS Lett 306:75-9 (1992) – [Pubmed]
25 — review article
Freemont P, Newman R, Driessen H
"Janus-faced proteins"
Curr Biol 2:98-100 (1992) – [Pubmed]
1991 (6)
24
Goddard AD, Borrow J, Freemont PS, Solomon E
"Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia"
Science 254:1371-4 (1991) – [Pubmed]
23
Freemont PS, Lane AN, Sanderson MR
"Structural aspects of protein-DNA recognition"
Biochem J 278:1-23 (1991) – [Pubmed]
22
Barton GJ, Newman RH, Freemont PS, Crumpton MJ
"Amino acid sequence analysis of the annexin super-gene family of proteins"
Eur J Biochem 198:749-60 (1991) – [Pubmed]
21
Freemont PS, Hanson IM, Trowsdale J
"A novel cysteine-rich sequence motif"
Cell 64:483-4 (1991) – [Pubmed]
20 — original research
Edgeworth J, Gorman M, Bennett R, Freemont P, Hogg N
"Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells"
J Biol Chem 266:7706-13 (1991) – [Pubmed]
19 — original research
Mazarakis ND, Nelki D, Lyon MF, Ruddy S, Evans EP, Freemont P, Dudley K
"Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex"
Development 111:561-71 (1991) – [Pubmed]
1990 (4)
18
Sanderson MR, Freemont PS, Rice PA, Goldman A, Hatfull GF, Grindley ND, Steitz TA
"The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 Å resolution"
Cell 63:1323-9 (1990) – [Pubmed]
17
Newman RH, Freemont PS, Barton GJ, Crumpton MJ
"Interaction of synthetic peptides from annexin I and uteroglobin with lipid monolayers and their effect on phospholipase A2 activity"
Biochem Soc Trans 18:1233-4 (1990) – [Pubmed]
16
Freemont PS
"A review of studies leading towards a three-dimensional understanding of the annexin family of proteins"
Biochem Soc Trans 18:1098-101 (1990) – [Pubmed]
15
Freemont PS, Driessen HP, Verbi W, Crumpton MJ
"Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV"
J Mol Biol 216:219-212 (1990) – [Pubmed]
1989 (4)
14 — book chapter
Joyce CM, Friedman JM, Beese L, Freemont PS, Steitz TA
"Structural model for the editing decision of Escherichia coli DNA polymerase I"
in DNA Replication and Mutagenesis (edited by Moses RE, Summers WC), American Society for Microbiology (1989)
13
Hatfull GF, Sanderson MR, Freemont PS, Raccuia PR, Grindley ND, Steitz TA
"Preparation of heavy-atom derivatives using site-directed mutagenesis. Introduction of cysteine residues into gamma delta resolvase"
J Mol Biol 208:661-7 (1989) – [Pubmed]
12 — original research
Edgeworth J, Freemont P, Hogg N
"Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14"
Nature 342:189-92 (1989) – [Pubmed]
11
Freemont P, Hogg N, Edgeworth J
"Sequence identity"
Nature 339:516 (1989) – [Pubmed]
1988 (6)
10
Freemont PS, Friedman JM, Beese LS, Sanderson MR, Steitz TA
"Cocrystal structure of an editing complex of Klenow fragment with DNA"
Proc Natl Acad Sci USA 85:8924-8 (1988) – [Pubmed]
9
Freemont PS, Rüger W
"Crystallization and preliminary X-ray studies of T4 phage β-glucosyltransferase"
J Mol Biol 203:525-6 (1988) – [Pubmed]
8
Sanderson MR, Freemont PS, Murthy HM, Krane JF, Summers WC, Steitz TA
"Purification and crystallization of thymidine kinase from herpes simplex virus type 1"
J Mol Biol 202:917-9 (1988) – [Pubmed]
7
Derbyshire V, Freemont PS, Sanderson MR, Beese L, Friedman JM, Joyce CM, Steitz TA
"Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I"
Science 240:199-201 (1988) – [Pubmed]
6
Freemont PS, Dunbar B, Fothergill-Gilmore LA
"The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase"
Biochem J 249:779-88 (1988) – [Pubmed]
5
Sawyer L, Fothergill-Gilmore LA, Freemont PS
"The predicted secondary structures of class I fructose-bisphosphate aldolases"
Biochem J 249:789-93 (1988) – [Pubmed]
1987 (1)
4
Steitz TA, Beese L, Freemont PS, Friedman JM, Sanderson MR
"Structural studies of Klenow fragment: An enzyme with two active sites"
Cold Spring Harb Symp Quant Biol 52:465-71 (1987) – [Pubmed]
1986 (2)
3
Freemont PS, Ollis DL, Steitz TA, Joyce CM
"A domain of the Klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity"
Proteins 1:66-73 (1986) – [Pubmed]
2
Steitz TA, Freemont PS, Ollis DL, Joyce CM, Grindley JM
"Functional implications of the Klenow fragment structure"
Biochem Soc Trans 14:205-7 (1986) – [Pubmed]
1984 (1)
1 — original research
Freemont PS, Dunbar B, Fothergill LA
"Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments"
Arch Biochem Biophys 228:342-52 (1984) – [Pubmed]