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Macromolecular Structure and Function

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Structures and mechanisms of key components in the DNA damage response

DNA is exposed to toxic chemicals, UV and other radiation and consequently tens of thousands of DNA bases are damaged each day in every human cell.  Cells have developed sophisticated systems using multi-subunit macromolecular complexes to detect, process and repair this damage in a highly controlled and coordinated fashion.  We are currently using a multi-disciplinary approach to provide a molecular understanding of some of the key events including signaling, chromatin remodeling and DNA damage repair itself.  These projects are in collaboration with Prof. Peter Burgers, Washington University in St Louis, Prof. Dale Wigley, Institute of Cancer Research, and Dr. Stephen West FRS, Cancer Research UK.